Blocking glutamate-mediated inferior olivary signals abolishes expression of conditioned eyeblinks but does not prevent their acquisition.

Assessing the role of inferior olivary sensory signaling in the expression of 1 conditioned eyeblinks using a combined glutamate / GABA - A receptor antagonist 2 protocol 3 4 5

Assessing the role of inferior olivary sensory signaling in the expression of 1 conditioned eyeblinks using a combined glutamate/GABA-A receptor antagonist 2 protocol 3 4 5 6 7 8 9 Svitlana Zbarska, Vlastislav Bracha 10 Biomedical Science Department, Iowa State University, Ames, IA, 50011 11 12 13 The inferior olive (IO) is a major component of the eyeblink conditioning neural 14 network. The c...

Assessing the role of inferior olivary sensory signaling in the expression of conditioned eyeblinks using a combined glutamate/GABAA receptor antagonist protocol.

The inferior olive (IO) is a major component of the eyeblink conditioning neural network. The cerebellar learning hypothesis assumes that the IO supplies the cerebellum with a "teaching" unconditioned stimulus input required for the acquisition of the conditioned response (CR) and predicts that inactivating this input leads to the extinction of CRs. Previous tests of this prediction attempted t...

The role of glutamatergic inferior olivary teaching signals in the acquisition of conditioned eyeblinks

Glutamate neurotransmission in the cerebellar interposed nuclei: involvement in classically conditioned eyeblinks and neuronal activity.

The cerebellar interposed nuclei (IN) are critical components of a neural network that controls the expression of classically conditioned eyeblinks. The IN receive 2 major inputs: the massive, gamma-aminobutyric acid (GABA)-mediated input from the Purkinje cells of the cerebellar cortex and the relatively weaker, glutamate-mediated input from collaterals of mossy and climbing fiber cerebellar a...

Changes in complex spike activity during classical conditioning

The cerebellar cortex is necessary for adaptively timed conditioned responses (CRs) in eyeblink conditioning. During conditioning, Purkinje cells acquire pause responses or "Purkinje cell CRs" to the conditioned stimuli (CS), resulting in disinhibition of the cerebellar nuclei (CN), allowing them to activate motor nuclei that control eyeblinks. This disinhibition also causes inhibition of the i...